What causes pitted keratolysis and how would you treat this condition?

How would you manage a case of pitted keratolysis?

How do we manage a case of Sneddon Wilkinson disease resistant to dapsone?

Subcorneal pustular dermatosis also known as Sneddon Wilkinson disease, was first described by Sneddon and Wikinson in 1956. It is rare, benign, chronic relapsing pustular eruption of unknown etiology. The condition which characteristically affects flexural aspects of trunk, has more commonly been reported in middle-aged and elderly women. A background history of paraproteinemia, multiple myeloma, pyoderma gangrenosum, inflammatory bowel disease, or rheumatoid arthritis may be present.

The primary lesions arise within a few hours as flaccid pustules on normal or very mildly erythematous skin. The pustules can be either isolated or grouped, and they tend to coalesce, forming annular, circinate, or serpiginous patterns. The eruption resolves, leaving mild hyperpigmentation, over which further waves of pustulation may arise. The condition is differentiated from acute generalized exanthematous pustulosis and pustular psoraisis by the absence of fever and systemic toxicity.

Most of the cases of subcorneal pustular dermatosis respond to dapsone and topical steroids. What are other treatment options for the cases resistant to the conventional therapy. View image in GSA View Dr.Amor's article in DOJ


Sneddon Wilkinson disease

How would you manage multiple epidermal cysts?

Proliferation of epidermal cells within a circumscribed space of the dermis gives rise to epidermal or epidermoid cysts. Epidermoid cysts of the genitals are common in the general population and may appear as a mass in the breast, the vulva, the clitoris, the penis, the scrotum, or the perineum. This young man developed multiple epidermoid cysts on the scrotum over several years. What should be the line of management in this case?
Epidermal cysts 

Role of ACD to compositae in the pathogenesis of CAD

Allergic contact dermatitis to compositae affects many people working outdoors in the fields. What is its role in the pathogenesis of chronic actinic dermatitis?

Chronic actinic dermatitis 

Differential diagnosis of a non healing ulcer

What would be the differential diagnosis for a non healing ulcer present on the nose of a young boy for at least six months ?

A non healing ulcer on the nose

Levofloxacin to treat an acute gonococcal infection

Let me share my eperience of treating acute gonorrhea with oral ciprofloxacin, ofloxacin and levofloxacin. I have found levofloxacin the most effective to treat an acute infection. What is your experience with oral drugs used to treat gonorrhea?

Intracellular diplococci