Linear IgA dermatosis resistent to oral dapsone and steroids
This 4-year-old boy presented with seven month history of developing a vesiculobullous eruption affecting the lower limbs, the buttocks, and the face. Physical examination revealed mutiple clear round vesicles, bullae and erosions on large erythematous back ground. Many of the bullae were arranged to depict string of beads and cluter of jewls signs. Oral mucosa was not involved. A tzank smear and gram stain were negative. Other tests are pending. How would you treat this patient if his condition fails to respond to oral dapsone and steroids?
Ayza Skin Research Center, Lalamusa, Pakistan View more images on Global Skin Atlas
1 Comments:
Dear Shahbaz,
Sulfapyridine could be tried in these circumstances. Other corticosteroid-sparing agents that may be beneficial include azathioprine, cyclosporine, and colchicine, but the risk-benefit profile for some of these therapies may not justify their use. Luckily most cases do respond to dapsone.
Best wishes
Ian.
5:19 AM
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